Taurolithocholic Acid Sodium Salt CAS 6042-32-6

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Product Name: Taurolithocholic acid sodium salt CAS 6042-32-6

 

5-Beta-Cholanic Acid-3-Alpha-OL N-(2-Sulphoethyl)-Amide Sodium Salt;

 

Appearance:White to off-white solid

Assay: NLT98%

Melting Point: 220-230 degree

Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml.

 

Application:Taurolithocholic acid sodium salt is a potent bile suppressant and a potent calcium ion agonist.Taurocholic acid (TLCA) at low concentrations (5µM) tends to selectively increase the membrane-associated fraction of PKC e-isoform by 44.1%±40.2% .TLCA (10µM) selectively induces the translocation of PKCε-isoforms to the liver cell membrane, which is a key step in activating mobile PKC isoforms.Taurocholic acid (TLCA) exerts bile inhibitory effects in perfused rat liver and rat hepatocyte conjugates via a PI3K-dependent mechanism.

 

 

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